G.M. Polselli, M. Di Genio, D. Accorrà, P.L. Bandinelli - Vol. 11, March 2005, Issue 1 - summary
Testo Immagini Bibliografia Summary Indice
Valutazione della terapia con olanzapina
nei pazienti ricoverati in SPDC
per disturbi schizofrenici, disturbi dell’umore e disturbi di personalità
Evaluation of the therapy with olanzapine of the inpatient with schizophrenic,
mood and personality disorders, in a psychiatric service for acute mental
disorders
Objective
In this study we aim at testing the efficacy
of olanzapine in patients treated in our hospitalization unit for acutely
ill patients and compare any differences in action related to gender, age,
diagnosis and drug formulation.
Method
Using the data of our intranet, we carried-out a naturalistic retrospective
study of 70 patients who were accepted for hospitalization at one time between
January 1999 and May 2002 and who took therapy with olanzapine. Patients were
selected according to exclusion criteria and subdivided into three groups
according to their diagnosis. The instruments used to rate clinical response
were the CGI and the BPRS; for statistical analysis we used the Kruskal-Wallis
test.
Results
A significant reduction in CGI scores was shown between beginning and
end of treatment, but no significant difference emerged for gender and age,
except for the side effect item, which was better in men than women. No significant
differences were obtained as regards treatment response according to various
diagnostic classes.
Conclusion
Besides confirming the efficacy of olanzapine in patients affected from
schizophrenic disorders and a good clinical response in mood disorders, our
study showed the usefulness of this substance in patients affected by personality
disorders. The possibility to expand the clinical indications for olanzapine
need to be confirmed. Patient age and substance formulation do not appear
to influence clinical response. Finally, inconsistent data were obtained regarding
gender, with premenopausal women responding better.