S. Bellino, E. Paradiso, M. Zizza, R. Di Lorenzo, F. Bogetto - Vol. 11, March 2005, Issue 1
Testo Immagini Bibliografia Summary Indice
Terapia combinata con psicoterapia interpersonale
di pazienti depressi maggiori
con disturbo borderline di personalità: confronto con la farmacoterapia
Combined therapy with interpersonal psychotherapy of major depressed
patients
with borderline personality disorder: a comparison with pharmacotherapy
Objective
The aim of the study is to assess clinical
response of patients with a major depressive episode (MDE) and concomitant
borderline personality disorder (BPD) to two treatment options: pharmacotherapy
with a serotonergic drug (SSRI) and combined therapy with SSRI and interpersonal
psychotherapy (IPT).
Methods
Thirty-nine BPD patients who presented a MDE were included. Seven patients
dropped-out for non-compliance. Thirty-two completed 6 months of treatment:
16 received citalopram 20-40 mg/day; 16 received combined therapy with citalopram
and IPT 1 session/week.
The two groups were compared with chi-square test and univariate General Linear
Model (GLM). Number of responders and mean change of global symptomatology
(CGI score) were not significantly different between groups. Statistical analysis
showed that combined therapy was superior to single therapy, when measuring
changes of depressive symptoms at Hamilton scale; psychological and social
functioning at the Satisfaction Profile (SAT-P); "vindictive/self-centered",
"cold/distant", and "intrusive/needy" scales at the Inventory
for Interpersonal Problems (IIP-64).
Conclusions
Combined therapy including interpersonal psychotherapy plus drug treatment
is more efficacious than drug treatment alone in treating depressed patients
with coexisting BPD, when considering a number of relevant factors: core symptoms
of depressive state, subjective quality of life and some features of interpersonal
problems that seem strictly related to borderline psychopathology.