R. CLEMENTE, G. BERSANI- Vol. 10, March 2004, Issue 1
Testo Immagini Bibliografia Summary Indice
Deficit cognitivi nella schizofrenia e profilo
di risposta ai diversi antipsicotici atipici
Cognitive deficits in schizophrenia and profile of response to different
atypical antipsychotics
Cognitive deficits have been reported in a large proportion of schizophrenic patients and appear to play an important role as predictors of poorer social functioning and worse clinical as well as functional outcome. Conventional neuroleptics, although they significantly improve positive symptoms of schizophrenia, appear unable to favourably affect the cognitive impairment associated to this illness. Recent evidence, on the other hand, appears to provide encouraging results on improvement on various aspects of neuropsychological performance with atypical antipsychotic treatment. In this paper, we reviewed the literature on the of effects clozapine, risperidone, olanzapine and quetiapine on cognitive functioning in schizophrenic patients. Reported data for each drug are reviewed separately in order to explore the hypothesis that the various atypical antipsychotics, on the basis of their different receptor profile, could show also different patterns of neuropsychological effects.