M. Mazza, A. De Risio, C. Tozzini, R. Roncone, M. Casacchia - Vol. 8, June 2002, Issue 2
Testo Immagini Bibliografia Summary Indice
Studio naturalistico in pazienti
depressi trattati con farmaci serotoninergici e noradrenergici:
valutazione clinica e cognitiva a sei mesi
A naturalistic study of patients treated
with serotonergic and noradrenergic drugs:
clinical and cognitive assessment at a 6-month follow-up
Introduction
Noradrenaline plays an importanat role in pathophysiology of depression. Some
antidepressant drugs act by facilitating noradrenergic transmission, regardless
to the availability of serotonine in the CNS. As demonstrated by experimentals
studies noradrenergic transmission mays be associated not only to attention,
but also to short-term memory and to social functioning measures.
Methods
In our study we have examined the performance in cognitive tasks, such as
attention and social functioning tasks, in two groups of subjects affected
by a Major Depressive Episode.
Subjects have been treated for six months with two different antidepressant
drugs (reboxetine vs citalopram).
Results and Conclusion
Results showed a significant improvement in cognitive functions in the groupe
treated with reboxetine.