R. Pollice, E. Daneluzzo, P. Stratta, M. Bustini, M.G. Marinangeli, P. Prosperini, A. Scinto, A. Rossi - Vol. 5, Giugno 1999, num.2
Testo Immagini Bibliografia Summary Riassunto Indice
Valutazione neurocomportamentale
premorbosa di pazienti affetti da disturbo schizofrenico: uno studio retrospettivo
con l’uso della cbcl
Premorbid neurobehavioural assessment
of patients with schizophrenia: a retrospective study using the Child Behavior
Checklist (CBCL)
Background and Objective: according to a neurodevelopmental
model of schizophrenia, premorbid neurobehavioural changes precede the clinical
onset of disease. To assess the presence of such changes, we performed a retrospective
neurobehavioural assessment in patients with DSM-IV schizophrenia and their
healthy siblings.
Methods: to obtain these data, we used the Child Behavior Checklist
(CBCL); we rated the scale based on retrospective maternal interviews reporting
on five age periods (birth to 3 years, 4 to 7 years, 8 to 11, 12 to 15, and
16 to 18). We also used the Krawiecka-Manchester Rating Scale (K-MRS) to rate
schizophrenia in adulthood.
Results: compared to their healthy siblings, patients had various behavioural
problems during childhood and adolescence; the nature of these problems differed
during the course of illness. Cluster analysis of childhood behaviour ratings
of schizophrenic siblings identified two patient subgroups: one with a high
level behaviour problems which increases over the years. The two subgroups
differed also in their M-KRS scores, in that the former scored higher on both
total scale and negative subscale. Further, an association between symptoms
and presence of specific neurobehavioural patterns was observed; the first
group had a more severe course and a prevalence of negative symptoms.
Conclusions: our results confirm the reliability of the CBCL and show
the existence of two prognostic subgroups of schizophrenia, one stable, with
a prevalence of negative symptoms and worse outcome and another progressive,
but less invalidating.