Autism Spectrum Disorder (ASD) has been recently highlighted as potentially related to a higher risk for suicide. ASD features are often under-recognized, especially in subjects with high level of functioning. We present the case of a 21-year-old man who attempted suicide jumping from the third floor of his home. The patient had been treated during the last 3 years for a Schizoaffective Disorder. Patient’s history showed the presence of signs and symptoms belonging to the realm of ASD. We hypothesize that the long-lasting presence of ASD features (instead of the schizoaffective symptomatology) was a clinically significant (but unrecognized) component that ultimately raised the suicide risk.