The COronaVIrus Disease 2019 (COVID-19) epidemic crisis caused the re-organization of different hospitals. A key factor in this process of answering mainly for functionality and health security was played by resilience, i.e., the ability to find and apply resources for support, engage in successful coping, or utilize other accessible protective factors. In the process of building a hospital that could show resilience, we adopted the emotional defusing that, by dealing with psychological distress of health care worker in our COVID-19 university hospital, has proven to be a technique at the basis of the growth of individual and group level.