The use of dietary supplements and herbal medicines is spreading across many developed countries. Although patients without specific problems can administer most, relevant toxicities might occur with a reckless use of dietary supplements, especially when psychiatric or medical comorbidities are present. Limited research is available on these compounds. We describe the case of a suspected intoxication due to a reckless use of a number of dietary supplements and herbal medicines (forty different compounds) in a patient with a history of recurrent depression and gromerulonephritis, hospitalized for acute cognitive and psychomotor impairments.